@misc{10481/74735,
year = {2022},
month = {2},
url = {http://hdl.handle.net/10481/74735},
abstract = {Liquid lipid nanocapsules are oil droplets surrounded by a protective shell, which enable high load and allow
controlled delivery of lipophilic compounds. However, their use in food formulations requires analysing their
digestibility and interaction with mucin. Here, serum albumins and hyaluronic acid shelled olive oil nanocapsules
are analysed to discern differences between human and bovine variants, the latter usually used as model
system. Interfacial interaction of albumins and hyaluronic acid reveals that human albumin presents limited
conformational changes upon adsorption, which increase by complexation with the polysaccharide present at the
interface. The latter also promotes hydrophobic interactions with mucin, especially at pH 3 and protects albumin
interfacial layer under in vitro gastric digestion. The interfacial unfolding induced in human albumin by hyaluronic
acid facilitates in vitro lipolysis while its limited conformational changes provide the largest protection
against in vitro lipolysis.},
organization = {Mancomunidad de los Pueblos de la Alpujarra Granadina},
organization = {Biocolloid and Fluid Physics Group of the University of Granada (Spain)	PAI-FQM115},
organization = {University of Granada	B11/56/1
Universidad de Granada/CBUA	
RTI2018-101309-B-C21
MCIN/AEI/10.13039/501100011033/FEDER
PID2020-116615RA-I00
MCIN/AEI/10.13039/501100011033},
publisher = {Elsevier},
keywords = {Albumin},
keywords = {Hyaluronic acid},
keywords = {Digestion},
keywords = {Mucin},
keywords = {Emulsion},
keywords = {Interfacial tension},
title = {Hyaluronic acid and human/bovine serum albumin shelled nanocapsules: Interaction with mucins and in vitro digestibility of interfacial films},
doi = {10.1016/j.foodchem.2022.132330},
author = {Castillo Santaella, Teresa del and Aguilera Garrido, Aixa María and Galisteo González, Francisco and Gálvez Ruiz, María José and Molina Bolívar, José Antonio and Maldonado Valderrama, Julia},
}