@misc{10481/74668,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/74668},
abstract = {Hematopoietic stem cell transplantation (HSCT) involves the infusion of either bone marrow
or blood cells preceded by toxic chemotherapy. However, there is little knowledge about the
clinical benefits of parenteral nutrition (PN) in patients receiving high-dose chemotherapy during
HSCT. We investigated the lipidomic profile of plasma and the targeted fatty acid profiles of plasma
and erythrocytes in children after HSCT using PN with either a fish oil-based lipid emulsion or a classic
soybean oil emulsion. An untargeted liquid chromatography high-resolution mass spectrometry
platform connected with a novel in silico annotation algorithm was utilized to determine the most relevant
chemical subclasses affected. In addition, we explored the interrelation between the lipidomics
profile in plasma, the targeted fatty acid profile in plasma and erythrocytes, several biomarkers
of inflammation, and antioxidant defense using an innovative data integration analysis based on
Latent Components. We observed that the fish oil-based lipid emulsion had an impact in several
lipid subclasses, mainly glycerophosphocholines (PC), glycerophosphoserines (PS), glycerophosphoethanolamines
(PE), oxidized PE (O-PE), 1-alkyl,2-acyl PS, lysophosphatidylethanolamines (LPE),
oxidized PS (O-PS) and dicarboxylic acids. In contrast, the classic soybean oil emulsion did not.
Several connections across the different blocks of data were found and aid in interpreting the impact
of the lipid emulsions on metabolic health.},
organization = {Junta de Andalucia
European Commission},
organization = {CIBERobn},
publisher = {MDPI},
keywords = {Bone marrow transplantation},
keywords = {Fat emulsions},
keywords = {Intravenous},
keywords = {Fatty acids},
keywords = {Omega-3},
keywords = {Hematopoietic stem cell transplantation},
keywords = {Lipidomics},
keywords = {Parenteral nutrition},
title = {The Metabolic Impact of Two Different Parenteral Nutrition Lipid Emulsions in Children after Hematopoietic Stem Cell Transplantation: A Lipidomics Investigation},
doi = {10.3390/ijms23073667},
author = {Rangel Huerta, Óscar Daniel and Mesa García, María Dolores and Gil Hernández, Ángel},
}