@misc{10481/74426,
year = {2022},
month = {2},
url = {http://hdl.handle.net/10481/74426},
abstract = {Breast cancer is the most common type of malignancy and leading cause of cancer death
among women worldwide. Despite the current revolutionary advances in the field of cancer immunotherapy,
clinical response in breast cancer is frequently below expectations, in part due to
various mechanisms of cancer immune escape that produce tumor variants that are resistant to
treatment. Thus, a further understanding of the molecular events underlying immune evasion in
breast cancer may guarantee a significant improvement in the clinical success of immunotherapy.
Furthermore, nanomedicine provides a promising opportunity to enhance the efficacy of cancer
immunotherapy by improving the delivery, retention and release of immunostimulatory agents in
targeted cells and tumor tissues. Hence, it can be used to overcome tumor immune escape and
increase tumor rejection in numerous malignancies, including breast cancer. In this review, we
summarize the current status and emerging trends in nanomedicine-based strategies targeting cancer
immune evasion and modulating the immunosuppressive tumor microenvironment, including the
inhibition of immunosuppressive cells in the tumor area, the activation of dendritic cells and the
stimulation of the specific antitumor T-cell response.},
organization = {Instituto de Salud Carlos III
European Commission	CP14/00197	
CP19/00029	
PI15/00336	
PI19/01533},
organization = {European Regional Development Fund (European Union)		
Instituto de Salud Carlos III},
organization = {Spanish Government},
organization = {European Commission	PID2020-115087GB-100	
RTI2018.101309B-C22},
organization = {Junta de Andalucia	B-CTS-410-UGR-20},
organization = {Sistema Nacional de Garantia Juvenil (Fondo Social Europeo)},
organization = {Fundacion Cientifica Asociacion Espanola Contra el Cancer, Junta Provincial de Jaen (AECC)	PRDJA19001BLAY	
Spanish Government	FPU19/04450},
organization = {Junta de Andalucia	RH-0139-2020},
organization = {Junta de Andalucia, Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades	DOC_01686},
publisher = {MDPI},
keywords = {Breast cancer},
keywords = {Nanomedicine},
keywords = {Immune escape},
keywords = {Cancer immunotherapy},
keywords = {Cancer treatment},
title = {Nanomedicine as a Promising Tool to Overcome Immune Escape in Breast Cancer},
doi = {10.3390/pharmaceutics14030505},
author = {Navarro Ocón, Alba and Blaya Cánovas, José Lucas and López Tejada, Araceli and Blancas López-Barajas, María Isabel and Sánchez Martín, Rosario María and Griñán Lisón, Carmen and Calahorra, Jesús and Cara, Francisca E. and Ruiz-Cabello Osuna, Francisco and Marchal Corrales, Juan Antonio and Aptsiauri, Natalia and Granados Principal, Sergio},
}