@misc{10481/74403,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/74403},
abstract = {Headache disorders (HDs) are among the most common conditions of the central nervous
system, with an estimated prevalence of 50% in adult population. The aim of this work is to analyze
the prevalence of structural anomalies that may explain HDs in MRI exams performed to rule out
secondary headache in real-world practice, as well as risk factors associated with these lesions. We
conducted a retrospective observational study based on a consecutive case series of all patients that
underwent brain MRI due to headache from 1 January 2019 to 31 May 2019. We included patients from
six MRI diagnostic centers accounting for four provinces of Andalusia (southern Spain). Bivariate
and multivariate logistical regression models were performed to identify risk factors associated
with the outcomes (1) presence of a structural finding potentially explaining headache, (2) presence
of intracranial space-occupying lesions (SOLs), and (3) presence of intracranial tumors (ITs). Of
the analyzed sample (1041 patients), a structural finding that could explain headache was found
in 224 (21.5%) patients. SOLs were found in 50 (6.8%) patients and ITs in 12 (1.5%) patients. The
main factors associated with structural abnormalities were female sex (OR, 1.35; 95% CI, 1.02–1.85),
accompanying symptoms (OR, 1.34; 95% CI, 1.05–1.89), use of gadolinium-based contrast agents
(OR, 1.89; 95% CI, 1.31–2.72) and previously known conditions potentially explaining headache
(OR, 2.44; 95% CI, 1.55–3.84). Female sex (p = 0.048) and accompanying symptoms (p = 0.033) were
also associated with ITs in bivariate analyses. Our results may be relevant for different medical
specialists involved in the diagnosis, management and prevention of headache. Moreover, the risk
factors identified in our study might help the development of public health strategies aimed at early
diagnosis of brain tumors. Future studies are warranted to corroborate our findings.},
organization = {MCIN/AEI/10.13039/501100011033
PID2020118224RB-I00},
publisher = {MDPI},
keywords = {Risk factors},
keywords = {Prevention},
keywords = {Neoplasms},
keywords = {Headache},
keywords = {Magnetic resonance imaging},
keywords = {Central nervous system},
title = {Prevalence and Risk Factors Associated with Tumors and Other Structural Anomalies in Brain MRI Performed to Rule out Secondary Headache: A Multicenter Observational Study},
doi = {10.3390/ijerph19063521},
author = {Martínez Barbero, José Pablo and Láinez Ramos-Bossini, Antonio Jesús and Rivera Izquierdo, Mario and Benítez Sánchez, José Manuel and Cervilla Ballesteros, Jorge Antonio},
}