@misc{10481/74158,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/74158},
abstract = {SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple “-omics” methods to assess
SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our
LUAD cohort (41.4%), and over 70% of the mutations were predicted to have functional impact. Furthermore, SWI/
SNF expression in LUAD suffered an overall repression that could not be explained exclusively by genetic alterations.
Finally, SWI/SNF mutations were associated with poorer overall survival in TCGA-LUAD. We propose SWI/SNF-mutant
LUAD as a separate clinical subgroup with practical implications.},
organization = {Spanish Government	SAF2015-67919-R	
DPI2017-84439-R},
organization = {Junta de Andalucia	P20-00688	
PI-0135-2020	
PIGE-0213-2020	
PIGE-0440-2019	
PI-0245-2017},
organization = {University of Granada	B-CTS-480-UGR20},
organization = {International Association for the Study of Lung Cancer (IASLC)},
organization = {Spanish Association for Cancer Research	LAB-AECC-2018},
organization = {La Caixa Foundation	LCF/BQ/DE15/10360019},
organization = {PhD FPI-fellowship	BES-2013-064596},
organization = {"Fundacion Benefica Anticancer Santa Candida y San Francisco Javier" predoctoral fellowship},
organization = {European Commission},
organization = {fellowship "Beca de Iniciacion a la Investigacion del Plan Propio de Investigacion 2019" by University of Granada		
Instituto de Salud Carlos III	PT17/0019},
organization = {European Commission	PT17/0019	
FPU17/00067	
FPU19/00576},
publisher = {BMC},
keywords = {Multi-omics},
keywords = {Lung cancer},
keywords = {Lung adenocarcinoma},
keywords = {SWI/SNF complex},
keywords = {Epigenetics},
keywords = {Prognosis},
title = {Multi‑omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma},
doi = {10.1186/s13148-022-01261-3},
author = {Peinado Fernández, Paola and Andrades Delgado, Álvaro and Cuadros Celorrio, Marta Eugenia and Rodríguez Lara, María Isabel and García García, Daniel Jesús and Benítez Cantos, María Soledad and Cano Gutiérrez, Carlos and Medina Vico, Pedro Pablo},
}