@misc{10481/74138,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/74138},
abstract = {Objectives. It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility
and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also
important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate
genes) and the gene–gene, gene–PA and gene–sedentary behaviour interactions with pain and pain-related
cognitions in women with FM.
Methods. Saliva samples from 274 women with FM [mean (S.D.) age 51.7 (7.7) years] were collected for extracting
DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires,
and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis
was also performed.
Results. The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually
related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid
receptor l gene, OPRM1) was related to pain catastrophizing. Five gene–behaviour interactions were significant:
the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular
body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale
of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and
severity of FM symptoms (codominant model, P-value 0.032).
Conclusion. The HTR2A gene (individually), COMT and OPRM1 gene–gene interaction, and the interactions
of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related
outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene–
sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should
examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic
susceptibility to pain.},
organization = {Spanish Government	I + D+i DEP2010-15639	
I + D+i DEP2013-40908-R	
BES-2014-067612	
FPU13/03410	
FPU15/0002},
organization = {Junta de Andalucia	CTCD-201000019242-TRA	
PI-0520-2016},
organization = {University of Granada, Plan Propio de Investigacion},
organization = {Unit of Excellence on Exercise and Health (UCEES)},
publisher = {Oxford University Press},
keywords = {Adrenoceptor alpha 1A gene},
keywords = {Charged multivesicular body protein 1A gene},
keywords = {5-hydroxytryptamine receptor 2A gene},
keywords = {Opioid receptor mu 1 gene},
keywords = {Sodium voltage-gated channel alpha subunit 9 gene},
title = {Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project},
doi = {10.1093/rheumatology/keab911},
author = {Guerrero González, Juan M. and Acosta Manzano, Pedro and Segura Jiménez, Víctor and Delgado Fernández, Manuel and Martínez González, Luis Javier and Ruiz Ruiz, Jonatan and Álvarez Cubero, María Jesús},
}