@misc{10481/74118,
year = {2022},
month = {2},
url = {http://hdl.handle.net/10481/74118},
abstract = {The relationship between depression and the Val66Met polymorphism at the brain-derived
neurotrophic factor gene (BDNF), has been largely studied. It has also been related to physical activity,
although the results remain inconclusive. The aim of this study is to investigate the relationship
between this polymorphism, depression and physical activity in a thoroughly characterised sample of
community-based individuals from the PISMA-ep study. A total of 3123 participants from the PISMAep
study were genotyped for the BDNF Val66Met polymorphism, of which 209 had depression.
Our results are in line with previous studies reporting a protective effect of physical activity on
depression, specifically in light intensity. Interestingly, we report a gene-environment interaction
effect in which Met allele carriers of the BDNF Val66Met polymorphism who reported more hours
of physical activity showed a decreased prevalence of depression. This effect was observed in the
total sample (OR = 0.95, 95%CI = 0.90–0.99, p = 0.027) and was strengthened in women (OR = 0.93,
95%CI = 0.87–0.98, p = 0.019). These results highlight the potential role of physical activity as a
promising therapeutic strategy for preventing and adjuvant treatment of depression and suggest
molecular and genetic particularities of depression between sexes.},
organization = {Junta de Andalucia	PI3222009},
organization = {Consejeria de Innovacion, Proyecto de Excelencia	CTS-2010-6682},
organization = {Institute of Health Carlos III (European Regional Development Fund/European Social Fund "A way to make Europe"/"Investing in your future")	PI18/00238	
PI18/00467},
organization = {Marie Curie Research Grants Scheme	FP7 626235},
organization = {NARSAD	22514},
organization = {Spanish Government	BES-2017-082698},
organization = {Spanish Ministry of Science and Innovation Juan de la Cierva Incorporacion Program	IJC2019-040080-I/AEI/10.13039/501100011033},
organization = {Ministry of Economy and Competitiveness},
organization = {Instituto de Salud Carlos III	FI19/00228},
organization = {Ministry of Economy and Competitiveness Ramon y Cajal Program	RYC-2014-15774},
publisher = {MDPI},
keywords = {Depression},
keywords = {Physical activity},
keywords = {BDNF},
keywords = {Val66Met},
keywords = {rs6265},
title = {Interaction Effect between Physical Activity and the BDNF Val66Met Polymorphism on Depression in Women from the PISMA-ep Study},
doi = {10.3390/ijerph19042068},
author = {Zarza Rebollo, Juan Antonio and Molina Rivas, Esther and López Isac, Elena and Pérez Gutiérrez, Ana María and Gutiérrez Martínez, Blanca and Cervilla Ballesteros, Jorge Antonio and Rivera Sánchez, Margarita},
}