@misc{10481/74116,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/74116},
abstract = {Olive leaves, one of the most abundant olive production by-products, have shown incredible
potential for their characteristic bioactive compound composition, with unique compounds such
as the polyphenol oleuropein. In order to evaluate the bioaccessibility of bioactive compounds
present in an olive leaf extract, samples were submitted to an in vitro digestion process following
INFOGEST protocol, and qualitative and quantitative characterization of the original extract and
digestive samples at different times were carried out using HPLC-ESI-TOF-MS. The analyzed extract
presented an abundance of phenolic compounds, such as secoiridoids, with oleuropein being the
main identified compound. The in vitro digestion process showed an effect on the phenolic profile of
the extract, with a lower recovery in the gastric phase and an increase at the beginning of the intestinal
phase. Most of the studied compounds showed high bioaccessibility at the end of the digestion,
with oleuropein, ligstroside, and quercetin-3-O-galactoside being among the ones with higher value.
These findings show the potential for future use of olive leaf polyphenols. However, further research
is needed in order to evaluate the absorption, delivery, and interaction of these compounds with
the colon.},
organization = {Spanish Government	RTI2018-096724-B-C22},
organization = {Junta de Andalucia	B-AGR-466-UGR18},
organization = {Ayudas a proyectos de I+D+I de entidades privadas calificadas como agentes del sistema andaluz del conocimiento	PY18-RE-0033},
organization = {Ayudas al funcionamiento de los Grupos operativos de la Asociacion Europea para la Innovacion (AEI) en materia de productividad y sostenibilidad agricolas en el sector del olivar, 2020	GOPOGR-20-0001},
organization = {Ayudas a los agentes publicos del Sistema Andaluz del Conocimiento, para la realizacion de proyectos de I+D+i	A-AGR-226-AGR20},
publisher = {MDPI},
keywords = {Olive leaf extract},
keywords = {Polyphenols},
keywords = {HPLC},
keywords = {In vitro digestion},
keywords = {Bioaccessibility},
title = {Characterization and Influence of Static In Vitro Digestion on Bioaccessibility of Bioactive Polyphenols from an Olive Leaf Extract},
doi = {10.3390/foods11050743},
author = {Duque Soto, Carmen and Quirantes Piné, Rosa and Borras Linares, María Isabel and Segura Carretero, Antonio and Lozano Sánchez, Jesús},
}