@misc{10481/73774,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/73774},
abstract = {Neurological disorders, including neurodegenerative diseases, are often characterized by
neuroinflammation, which is largely driven by microglia, the resident immune cells of the central
nervous system (CNS). Under these conditions, microglia are able to secrete neurotoxic substances,
provoking neuronal cell death. However, microglia in the healthy brain carry out CNS-supporting
functions. This is due to the ability of microglia to acquire different phenotypes that can play a
neuroprotective role under physiological conditions or a pro-inflammatory, damaging one during
disease. Therefore, therapeutic strategies focus on the downregulation of these neuroinflammatory
processes and try to re-activate the neuroprotective features of microglia. Mesenchymal stem cells
(MSC) of different origins have been shown to exert such effects, due to their immunomodulatory
properties. In recent years, MSC derived from adipose tissue have been made the center of attention
because of their easy availability and extraction methods. These cells induce a neuroprotective
phenotype in microglia and downregulate neuroinflammation, resulting in an improvement of
clinical symptoms in a variety of animal models for neurological pathologies, e.g., Alzheimer’s
disease, traumatic brain injury and ischemic stroke. In this review, we will discuss the application
of adipose tissue-derived MSC and their conditioned medium, including extracellular vesicles, in
neurological disorders, their beneficial effect on microglia and the signaling pathways involved.},
organization = {Andalusian Government, Spain P20-01255},
organization = {FEDER program grant no. A1-CTS-324-UGR18},
organization = {Spanish Ministry for
Economy and Competition, Spain (grant no. SAF2017-85602-R and PID2020-119638RB-I00)},
organization = {Research Starting Fellowship for master´s students at the
University of Granada, Spain},
organization = {MDPI},
publisher = {MDPI},
keywords = {Adipose tissue-derived mesenchymal stem cells},
keywords = {Extracellular vesicles},
keywords = {Microglia},
keywords = {Neurodegenerative diseases},
keywords = {Neuroinflammation},
keywords = {Neuroprotection},
title = {Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases},
doi = {10.3390/biom12020219},
author = {Sánchez Castillo, Ana Isabel and Sepúlveda Justo, María Del Rosario and Marín Teva, José Luis and Cuadros Ojeda, Miguel Ángel and Martín Oliva, Francisco David and González Rey, Elena and Delgado, Mario and Neubrand, Veronika Elisabeth},
}