@misc{10481/73658,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/73658},
abstract = {Allium species and their organosulfur-derived compounds could prevent obesity and
metabolic dysfunction, as they exhibit immunomodulatory and antimicrobial properties. Here, we
report the anti-obesogenic potential and dose-dependent effects (0.1 or 1 mg/kg/day) of propyl
propane thiosulfinate (PTS) in a murine model of diet-induced obesity. The obesogenic diet increased
body weight gain and adipocyte size, and boosted inflammatory marker (Cd11c) expression in the
adipose tissue. Conversely, PTS prevented these effects in a dose-dependent manner. Moreover, the
higher dose of PTS improved glucose and hepatic homeostasis, modulated lipid metabolism, and
raised markers of the thermogenic capacity of brown adipose tissue. In the colon, the obesogenic diet
reduced IL-22 levels and increased gut barrier function markers (Cldn3, Muc2, Reg3g, DefaA); however,
the highest PTS dose normalized all of these markers to the levels of mice fed a standard diet. Gut
microbiota analyses revealed no differences in diversity indexes and only minor taxonomic changes,
such as an increase in butyrate producers, Intestimonas and Alistipes, and a decrease in Bifidobacterium
in mice receiving the highest PTS dose. In summary, our study provides preclinical evidence for
the protective effects of PTS against obesity, which if confirmed in humans, might provide a novel
plant-based dietary product to counteract this condition.},
organization = {Spanish Government},
organization = {European Commission	PID2020-119536RB-I00	
CIEN IDI-20170847},
organization = {Spanish Government	FPU 18/02026},
organization = {contract Juan de la Cierva-Incorporacion	IJCI-2017-32485},
publisher = {MDPI},
keywords = {Obesity},
keywords = {Microbiota},
keywords = {Propyl propane thiosulfinate},
keywords = {Allium},
keywords = {Dose effect},
title = {The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity},
doi = {10.3390/nu14030440},
author = {Liébana García, Rebeca and Rodríguez Ruano, Sonia and Gil Martínez, Lidia and Guillamón, Enrique and Baños, Alberto},
}