@misc{10481/73608,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/73608},
abstract = {Multidrug-resistant Gram-negative bacteria (MDR-GNB) are microorganisms that have
acquired resistance to extended-spectrum antibacterials and constitute an emerging threat to public
health. Although carriers are an important source of transmission in healthcare settings, data about
risk factors for MDR-GNB carriage are limited. Therefore, we aimed to identify risk factors for
MDR-GNB carriage upon intensive care unit (ICU) admission and to optimise screening strategies.
We conducted a case–control study. Admissions of adult patients to the ICU of a 1000-bed hospital
during a year were included. We collected sociodemographic, clinical and microbiological data and
performed a multivariate logistic regression model. A total of 1342 patients resulted in 1476 episodes
of ICU admission, 91 (6.2%) of whom harboured MDR-GNB (38.5% women; median age 63.9 years).
The most frequently isolated pathogens were Escherichia coli (57%) and Klebsiella pneumoniae (16%).
The most frequent resistance mechanism was production of extended-spectrum beta lactamases.
MDR-GNB carriage was associated to liver cirrhosis (OR 6.54, 95% CI 2.17–19.17), previous MDRGNB
carriage (OR 5.34, 1.55–16.60), digestive surgery (OR 2.83, 1.29–5.89) and length of hospital
stay (OR 1.01 per day, 1.00–1.03). Several risk factors for MDR-GNB carriage upon admission to a
high-risk setting were identified; the main comorbidity was liver cirrhosis.},
publisher = {MDPI},
keywords = {Antibacterial drug resistance},
keywords = {Critical care},
keywords = {Infection control},
keywords = {Risk factors},
keywords = {Gram negative bacteria},
keywords = {Epidemiology},
title = {Risk Factors for Multidrug-Resistant Gram-Negative Bacteria Carriage upon Admission to the Intensive Care Unit},
doi = {10.3390/ijerph19031039},
author = {Fernández Martínez, Nicolás Francisco and Cárcel Fernández, Sheila and Gómez Jiménez, Francisco J.},
}