@misc{10481/73585,
year = {2021},
month = {10},
url = {http://hdl.handle.net/10481/73585},
abstract = {Context: Bile acids (BA) are known for their role in intestinal lipid absorption and can
also play a role as signaling molecules to control energy metabolism. Prior evidence
suggests that alterations in circulating BA levels and in the pool of circulating BA are
linked to an increased risk of obesity and a higher incidence of type 2 diabetes in middleaged
adults. Objective: We aimed to investigate the association between plasma levels of BA with
cardiometabolic risk factors in a cohort of well-phenotyped, relatively healthy young
adults.
Methods: Body composition, brown adipose tissue, serum classical cardiometabolic
risk factors, and a set of 8 plasma BA (including glyco-conjugated forms) in 136 young
adults (age 22.1 ± 2.2 years, 67% women) were measured.
Results: Plasma levels of chenodeoxycholic acid (CDCA) and glycoursodeoxycholic acid
(GUDCA) were higher in men than in women, although these differences disappeared after
adjusting for body fat percentage. Furthermore, cholic acid (CA), CDCA, deoxycholic acid
(DCA), and glycodeoxycholic acid (GDCA) levels were positively, yet weakly associated,
with lean body mass (LBM) levels, while GDCA and glycolithocholic acid (GLCA) levels
were negatively associated with 18F-fluorodeoxyglucose uptake by brown adipose
tissue. Interestingly, glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), and
GUDCA were positively associated with glucose and insulin serum levels, HOMA index,
low-density lipoprotein cholesterol, tumor necrosis factor alpha, interleukin (IL)-2, and
IL-8 levels, but negatively associated with high-density lipoprotein cholesterol, ApoA1,
and adiponectin levels, yet these significant correlations partially disappeared after the
inclusion of LBM as a confounder.
Conclusion: Our findings indicate that plasma levels of BA might be sex dependent
and are associated with cardiometabolic and inflammatory risk factors in young and
relatively healthy adults.},
organization = {Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad	DEP2016-79512-R},
organization = {European Commission		
Spanish Government	FPU 16/02828},
organization = {University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Consejeria de Conocimiento, Investigacion y Universidades (ERDF)	SOMM17/6107/UGR},
organization = {Netherlands CardioVascular Research Initiative "the Dutch Heart Foundation"	CVON2017-20 GENIUS-2	
Netherlands CardioVascular Research Initiative "Dutch Federation of University Medical Centers"	CVON2017-20 GENIUS-2},
organization = {Netherlands CardioVascular Research Initiative "Netherlands Organisation for Health Research and Development"	CVON2017-20 GENIUS-2	
Netherlands CardioVascular Research Initiative "Royal Netherlands Academy of Sciences"	CVON2017-20 GENIUS-2},
organization = {China Scholarship Council	201707060012	
201607060017},
organization = {Fundacion Alfonso Martin Escudero},
organization = {Junta de Andalucia},
publisher = {Oxford University Press},
keywords = {Biomarkers},
keywords = {Cardiometabolic Risk},
keywords = {Brown adipose tissue},
keywords = {Dyslipidemia},
keywords = {Insulin resistance},
title = {Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults},
doi = {10.1210/clinem/dgab773},
author = {Osuna Prieto, Francisco Javier and Rubio López, José and Ruiz Ruiz, Jonatan and Martínez Téllez, Borja Manuel},
}