@misc{10481/73069,
year = {2022},
month = {2},
url = {http://hdl.handle.net/10481/73069},
abstract = {Progressive multifocal leukoencephalopathy (PML) is a rare complication of immunosuppressive treatment in MS patients. Immune reconstitution inflammatory syndrome (IRIS) appears after the withdrawal of certain drugs such as natalizumab (NTZ) or fingolimod. The development of PML-IRIS after NTZ treatment has been described, and its diagnosis is made by clinical and radiological criteria and the determination of the John Cunningham virus in CSF. We present a clinical case of a patient with MS who, after the withdrawal of fingolimod, developed PML-IRIS despite sustained lymphopenia. This is important for pharmacovigilance purposes, not only for NTZ but also for alternative drugs used in MS treatment.},
publisher = {S. Karger AG},
keywords = {Fingolimod},
keywords = {Immune reconstitution inflammatory syndrome},
keywords = {Magnetic resonance imaging},
keywords = {Multiple sclerosis},
keywords = {Progressive multifocal leukoencephalopathy},
title = {Progressive Multifocal  Leukoencephalopathy and  Immune Reconstitution Inflammatory  Syndrome after Discontinuation of  Fingolimod},
doi = {10.1159/000521944},
author = {Piñar Morales, Raquel and Carrasco Garcia, María and Gutiérrez Rojas, Luis and Barrero Hernández, Francisco Javier},
}