@misc{10481/72949,
year = {2022},
month = {2},
url = {http://hdl.handle.net/10481/72949},
abstract = {Purpose Diet may play an essential role in the aetiology of bladder cancer (BC). The B group complex vitamins involve
diverse biological functions that could be influential in cancer prevention. The aim of the present study was to investigate
the association between various components of the B group vitamin complex and BC risk.
Methods Dietary data were pooled from four cohort studies. Food item intake was converted to daily intakes of B group
vitamins and pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were obtained
using Cox-regression models. Dose–response relationships were examined using a nonparametric test for trend.
Results In total, 2915 BC cases and 530,012 non-cases were included in the analyses. The present study showed an increased
BC risk for moderate intake of vitamin B1 (
HRB1: 1.13, 95% CI: 1.00–1.20). In men, moderate intake of the vitamins B1,
B2, energy-related vitamins and high intake of vitamin B1 were associated with an increased BC risk (HR (95% CI): 1.13
(1.02–1.26), 1.14 (1.02–1.26), 1.13 (1.02–1.26; 1.13 (1.02–1.26), respectively). In women, high intake of all vitamins and
vitamin combinations, except for the entire complex, showed an inverse association (HR (95% CI): 0.80 (0.67–0.97), 0.83
(0.70–1.00); 0.77 (0.63–0.93), 0.73 (0.61–0.88), 0.82 (0.68–0.99), 0.79 (0.66–0.95), 0.80 (0.66–0.96), 0.74 (0.62–0.89), 0.76
(0.63–0.92), respectively). Dose–response analyses showed an increased BC risk for higher intake of vitamin B1 and B12.
Conclusion Our findings highlight the importance of future research on the food sources of B group vitamins in the context
of the overall and sex-stratified diet.},
organization = {World Cancer Research Fund International (WCRF)	WCRF 2012/590},
organization = {European Commission
European Commission Joint Research Centre	FP7-PEOPLE-618308},
organization = {KWF Kankerbestrijding},
organization = {Radiation Effects Research Foundation (RERF)},
organization = {Hiroshima and Nagasaki, Japan		
public interest foundation - Japanese Ministry of Health, Labour and Welfare (MHLW)},
organization = {United States Department of Energy (DOE)		
DE-HS0000031},
organization = {RERF Research Protocol	RP-A5-12},
organization = {United States Department of Health & Human Services},
organization = {National Institutes of Health (NIH) - USA},
organization = {NIH National Cancer Institute (NCI)	R01CA74846},
organization = {European Commission
European Commission Joint Research Centre},
organization = {Ligue contre le Cancer (France)		
3M},
organization = {Mutuelle Generale de l'Education Nationale},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Institute Gustave Roussy},
organization = {Deutsche Krebshilfe},
organization = {German Cancer Research Centre},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Danish Cancer Society},
organization = {Instituto de Salud Carlos III},
organization = {Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra},
organization = {UK Research & Innovation (UKRI)
Medical Research Council UK (MRC)
Cancer Research UK		
Stroke Association, UK},
organization = {British Heart Foundation		
Department of Health, UK		
Food Standards Agency, UK},
organization = {Wellcome Trust},
organization = {Greek Ministry of Development-GSRT},
organization = {Fondazione AIRC per la ricerca sul cancro		
Consiglio Nazionale delle Ricerche (CNR)},
organization = {Dutch Ministry of Public Health, Welfare and Sports		
Dutch Prevention Funds},
organization = {LK Research Funds},
organization = {Netherlands Organization for Scientific Research (NWO)},
organization = {World Cancer Research Fund International (WCRF)},
organization = {Swedish Cancer Society		
Swedish Scientific Council		
Regional Government of Skane, Sweden},
organization = {Norwegian Cancer Society		
Research Council of Norway},
organization = {European Commission},
organization = {Centre de Recherche et d'Information Nutritionnelles (CERIN)},
publisher = {Springer},
keywords = {Nutritional oncology},
keywords = {Bladder cancer},
keywords = {Pooled cohort analysis},
keywords = {B group vitamins},
title = {Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies},
doi = {10.1007/s00394-022-02805-2},
author = {Boot, Iris W. A. and Sánchez Pérez, María José},
}