@misc{10481/72900,
year = {2021},
month = {9},
url = {http://hdl.handle.net/10481/72900},
abstract = {Background: Observational studies have consistently reported that postmenopausal hormone therapy use is associated with
lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of
endogenous estrogens and colorectal cancer have reported inconsistent results. Methods: We investigated the associations
between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione,
dehydroepiandrosterone (DHEA), progesterone, and sex hormone–binding globulin (SHBG) with colon cancer risk in a nested
case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent
users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to
compute odds ratios and 95% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with
colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. Results: In the
multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon
cancer risk (odds ratio per log2 1-unit increment¼1.17 [95% confidence interval¼1.00 to 1.38]; odds ratioquartile4-quartile1¼1.33
[95% confidence interval¼0.89 to 1.97], Ptrend¼.20). Circulating concentrations of estradiol, free estradiol, testosterone, free
testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the doseresponse
meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations
with colorectal, colon, and rectal cancer risk. Conclusion: Our observational and meta-analysis results do not support
an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal
women.},
organization = {French National Cancer Institute (INCa SHSESP17)	2017-127},
organization = {World Health Organization},
organization = {Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London},
organization = {Danish Cancer Society},
organization = {Ligue Contre le Cancer (France)},
organization = {Institut Gustave Roussy (France)},
organization = {Mutuelle Generale de l'Education Nationale (France)},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe		
German Cancer Research Center (DKFZ) (Germany)		
German Institute of Human Nutrition Potsdam Rehbruecke (DIfE) (Germany)},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Compagnia di San Paolo		
Consiglio Nazionale delle Ricerche (CNR)},
organization = {Netherlands Government},
organization = {World Cancer Research Fund International (WCRF)},
organization = {Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain)		
Junta de Andalucia		
Regional Government of Asturias (Spain)		
Regional Government of Basque Country (Spain)		
Regional Government of Murcia (Spain)		
Regional Government of Navarra (Spain)		
Catalan Institute of Oncology-ICO (Spain)},
organization = {Swedish Cancer Society		
Swedish Research Council		
County Council of Skane (Sweden)		
County Council of Vasterbotten (Sweden)},
organization = {Cancer Research UK	14136	
C8221/A29017	
UK Research & Innovation (UKRI)
Medical Research Council UK (MRC)	1000143	
MR/M012190/1},
publisher = {Oxford University Press},
title = {Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis},
doi = {10.1093/jncics/pkab084},
author = {Mori, Nagisa and Sánchez Pérez, María José},
}