@misc{10481/72795,
year = {2021},
month = {9},
url = {http://hdl.handle.net/10481/72795},
abstract = {BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more
frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology,
which is partially shared and partially distinct from that of related psychiatric disorders.
METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and
519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on
psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove
genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic
architectures of SA, psychiatric disorders, and other known risk factors.
RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an
intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on
psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has
been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with
psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep
disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general
health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders
decreased, whereas those with nonpsychiatric traits remained largely unchanged.
CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and
suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.},
organization = {Office of Research Infrastructure of the National Institutes of Health	S10OD018522	
S10OD026880},
organization = {United States Department of Health & Human Services},
organization = {National Institutes of Health (NIH) - USA	R01MH116269	
R01MH121455},
organization = {United States Department of Health & Human Services},
organization = {NIH National Institute of General Medical Sciences (NIGMS)	T32GM007347	
NARSAD	29551},
publisher = {Elsevier},
title = {Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors},
doi = {10.1016/j.biopsych.2021.05.029},
author = {Mullins, Niamh and Cervilla Ballesteros, Jorge Antonio and Gutiérrez Martínez, Blanca and Molina Rivas, Esther and Rivera Sánchez, Margarita and Psychiat Genomics Consortium and German Borderline Genomics Consort and MVP Suicide Exemplar Workgrp and VA Million Vet Program},
}