@misc{10481/72727,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/72727},
abstract = {Ag2S nanoparticles are near-infrared (NIR) probes providing emission in a specific spectral
range (~1200 nm), and superparamagnetic iron oxide nanoparticles (SPION) are colloidal systems able
to respond to an external magnetic field. A disadvantage of Ag2S NPs is the attenuated luminescent
properties are reduced in aqueous media and human fluids. Concerning SPION, the main drawback is
the generation of undesirable clusters that reduce particle stability. Here, we fabricate biocompatible
hybrid nanosystems combining Ag2S NPs and SPION by the electrospraying technique for drug
delivery purposes. These nanostructures are composed of poly(lactic-co-glycolic acid) (PLGA) as
the polymeric matrix in connection with both Ag2S NPs and SPIONs. Initially, we fabricate a hybrid
colloidal nanosystem composed of Ag2S NPs in connection with PLGA (PLGA@Ag2S) by three
different routes, showing good photoluminescent (PL) properties with relatively high average decay
times. Then, we incorporate SPIONs, obtaining a PLGA polymeric matrix containing both Ag2S
NPs and SPION (PLGA@Ag2S@SPION). Interestingly, in this hybrid system, the location of Ag2S
NPs and SPIONs depends on the synthesis route performed during electrospraying. After a detailed
characterization, we demonstrate the encapsulation and release capabilities, obtaining the kinetic
release using a model chemotherapeutic drug (maslinic acid). Finally, we perform in vitro cytotoxicity
assays using drug-loaded hybrid systems against several tumor cell lines.},
organization = {Comunidad de Madrid	2018-T1/IND-10736	
IND2020/BIO-17523},
organization = {Universidad Complutense de Madrid	CT63/19-CT64/19},
organization = {Junta de Andalucia	P18-HO-3882	
P20_00540	
A-CTS666-UGR20-FEDER},
organization = {Instituto de Salud Carlos III
European Commission	PI19/01478-FEDER	
DTS20/00109},
organization = {Spanish government (MICIU) through the Ramon y Cajal research program	RyC2019-028414-I},
organization = {Comunidad de Madrid	2017T1/BIO-4992},
publisher = {MDPI},
keywords = {Electrospraying},
keywords = {Ag2S nanoparticles},
keywords = {SPIONs},
keywords = {Hybrid system},
keywords = {Chemotherapeutic drug},
keywords = {Drug release},
title = {Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability},
doi = {10.3390/pharmaceutics14010214},
author = {Alvear Jiménez, Alexis and García Pinel, Beatriz and Prados Salazar, José Carlos and Melguizo Alonso, Consolación},
}