@misc{10481/72704,
year = {2021},
month = {3},
url = {http://hdl.handle.net/10481/72704},
abstract = {Background: The role of obesity and weight change in breast-cancer development is
complex and incompletely understood. We investigated long-term weight change and
breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status,
hormone replacement therapy (HRT) and hormone-receptor status. Methods: Using data on weight collected at three different time points from women who
participated in the European Prospective Investigation into Cancer and Nutrition (EPIC)
study, we investigated the association between weight change from age 20 years until
middle adulthood and risk of breast cancer.
Results: In total, 150 257 women with a median age of 51 years at cohort entry were
followed for an average of 14 years (standard deviation¼3.9) during which 6532
breast-cancer cases occurred. Compared with women with stable weight (62.5 kg),
long-term weight gain >10 kg was positively associated with postmenopausal
breast-cancer risk in women who were lean at age 20 [hazard ratio (HR)¼1.42; 95%
confidence interval 1.22–1.65] in ever HRT users (HR¼1.23; 1.04–1.44), in never HRT
users (HR¼1.40; 1.16–1.68) and in oestrogen-and-progesterone-receptor-positive
(ERþPRþ) breast cancer (HR¼1.46; 1.15–1.85).
Conclusion: Long-term weight gain was positively associated with postmenopausal
breast cancer in women who were lean at age 20, both in HRT ever users and non-users,
and hormone-receptor-positive breast cancer.},
organization = {European Commission (DG-SANCO)},
organization = {International Agency for Research on Cancer},
organization = {Danish Cancer Society (Kraftens Bekampelse)},
organization = {German Cancer Aid},
organization = {German Cancer Research Center},
organization = {Federal Ministry of Education and Research},
organization = {Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council},
organization = {Swedish Cancer Society},
organization = {Swedish Research Council},
organization = {County Councils of Skane and Vasterbotten},
organization = {14136	Cancer Research UK},
organization = {C570/A16491	EPIC-Norfolk},
organization = {1000143	Medical Research Council},
organization = {Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC)},
publisher = {Oxford University Press},
keywords = {Long-term weight change},
keywords = {Breast cancer},
keywords = {Cohort study},
title = {Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
doi = {10.1093/ije/dyab032},
author = {Ellingjord Dale, Merete and Sánchez Pérez, María José},
}