@misc{10481/72670,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/72670},
abstract = {Exercise and physical activity induces physiological responses in organisms, and adaptations
in skeletal muscle, which is beneficial for maintaining health and preventing and/or treating
most chronic diseases. These adaptations are mainly instigated by transcriptional responses that
ensue in reaction to each individual exercise, either resistance or endurance. Consequently, changes
in key metabolic, regulatory, and myogenic genes in skeletal muscle occur as both an early and late
response to exercise, and these epigenetic modifications, which are influenced by environmental and
genetic factors, trigger those alterations in the transcriptional responses. DNA methylation and histone
modifications are the most significant epigenetic changes described in gene transcription, linked
to the skeletal muscle transcriptional response to exercise, and mediating the exercise adaptations.
Nevertheless, other alterations in the epigenetics markers, such as epitranscriptomics, modifications
mediated by miRNAs, and lactylation as a novel epigenetic modification, are emerging as key events
for gene transcription. Here, we provide an overview and update of the impact of exercise on
epigenetic modifications, including the well-described DNA methylations and histone modifications,
and the emerging modifications in the skeletal muscle. In addition, we describe the effects of exercise
on epigenetic markers in other metabolic tissues; also, we provide information about how systemic
metabolism or its metabolites influence epigenetic modifications in the skeletal muscle.},
organization = {"Fundacion Ramon Areces", Madrid, Spain},
organization = {Spanish Government "Agencia Estatal de Investigacion-Juan de la Cierva-Incorporacion" program	IJC2020-042739-I},
organization = {Project "Transductores Moleculares del Ejercicio Fisico y la Activacion del Tejido Adiposo Pardo: en Busca de Nuevas Dianas Terapeuticas en la Comunicacion Intercelular" - "Consejeria de Economia, Conocimiento, Empresas y Universidad, Junta de Andalucia",	PY18-4455},
publisher = {MDPI},
keywords = {Epigenetics},
keywords = {Exercise},
keywords = {Physical activity},
keywords = {Skeletal muscle},
keywords = {Metabolism},
title = {Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism},
doi = {10.3390/biomedicines10010126},
author = {Plaza Díaz, Julio and Izquierdo, David and Torres Martos, Álvaro and Aguilera García, Concepción María and Ruiz Ojeda, Francisco Javier},
}