@misc{10481/72637,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/72637},
abstract = {Head and neck cancer is a growing worldwide public health problem, accounting for
approximately 1,500,000 new cases and 500,000 deaths annually. Substance P (SP) is a peptide of
the tachykinin family, which has roles related to a large number of physiological mechanisms in
humans. The implications of SP in carcinogenesis have recently been reported through the stimulation
of the neurokinin 1 receptor (NK1R), or directly, through the effects derived from the constitutive
activation of NK1R. Consequently, SP/NK1R seems to play relevant roles in cancer, upregulating cell
proliferation, cell migration and chronic inflammation, among other oncogenic actions. Furthermore,
there is growing evidence pointing to a central role for SP in tumour progression, singularly so in
laryngeal and oral squamous cell carcinomas. The current narrative review of the literature focuses
on the relationship between the SP/NK1R system and chronic inflammation and cancer in the headand-
neck region. We described a role for SP/NK1R in the transition from chronic inflammation of the
head and neck mucosa, to preneoplastic and neoplastic transformation and progression.},
publisher = {MDPI},
keywords = {Substance P},
keywords = {NK1R},
keywords = {Head and neck cancer},
keywords = {Squamous cell carcinoma},
keywords = {Chronic inflammation},
title = {Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature},
doi = {10.3390/ijerph19010375},
author = {Esteban, Francisco and Ramos García, Pablo and González Moles, Miguel Ángel},
}