@misc{10481/72568,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/72568},
abstract = {We tested whether physiological doses of hydroxytyrosol (HT) may alter the mRNA transcription
of key metabolic genes in exercised skeletal muscle. Two groups of exercise-trained Wistar
rats, HTlow and HTmid, were supplemented with 0.31 and 4.61 mg/kg/d of HT, respectively, for
10 weeks. Another two groups of rats were not supplemented with HT; one remained sedentary
and the other one was exercised. After the experimental period, the soleus muscle was removed
for qRT-PCR and western blot analysis. The consumption of 4.61 mg/kg/d of HT during exercise
increased the mRNA expression of important metabolic proteins. Specifically, 4.61 mg/kg/d of HT
may upregulate long-chain fatty acid oxidation, lactate, and glucose oxidation as well as mitochondrial
Krebs cycle in trained skeletal muscle. However, a 4.61 mg/kg/d of HT may alter protein
translation, as in spite of the increment showed by CD36 and GLUT4 at the mRNA level this was not
translated to higher protein content.},
organization = {3650
CTS-454},
publisher = {MDPI},
keywords = {Polyphenols},
keywords = {Mitochondria},
keywords = {Glycolysis},
keywords = {Gene expression},
title = {Physiological Doses of Hydroxytyrosol Modulate Gene Expression in Skeletal Muscle of Exercised Rats},
doi = {10.3390/life11121393},
author = {Casuso Pérez, Rafael Antonio and Al Fazazi, Saad and Plaza Díaz, Julio and Ruiz Ojeda, Francisco Javier and Rueda Robles, Ascensión and Aragón Vela, Jerónimo and Rodríguez Huertas, Jesús Francisco},
}