@misc{10481/72559,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/72559},
abstract = {Increasing prevalence of metabolic syndrome (MetS) is causing a significant health burden
among the European population. Current knowledge supports the notion that endocrine-disrupting
chemicals (EDCs) interfere with human metabolism and hormonal balance, contributing to the
conventionally recognized lifestyle-related MetS risk factors. This review aims to identify epidemiological
studies focusing on the association between MetS or its individual components (e.g., obesity,
insulin resistance, diabetes, dyslipidemia and hypertension) and eight HBM4EU priority substances
(bisphenol A (BPA), per- and polyfluoroalkyl substances (PFASs), phthalates, polycyclic aromatic
hydrocarbons (PAHs), pesticides and heavy metals (cadmium, arsenic and mercury)). Thus far,
human biomonitoring (HBM) studies have presented evidence supporting the role of EDC exposures
on the development of individual MetS components. The strength of the association varies between
the components and EDCs. Current evidence on metabolic disturbances and EDCs is still limited and
heterogeneous, and mainly represent studies from North America and Asia, highlighting the need
for well-conducted and harmonized HBM programmes among the European population. Rigorous
and ongoing HBM in combination with health monitoring can help to identify the most concerning
EDC exposures, to guide future risk assessment and policy actions.},
organization = {European Commission	733032},
publisher = {MDPI},
keywords = {Metabolic syndrome},
keywords = {Endocrine disrupting chemicals},
keywords = {Human biomonitoring},
keywords = {HBM4EU},
keywords = {Obesity},
keywords = {Insulin resistance},
keywords = {Diabetes},
keywords = {Dyslipidemia},
keywords = {Hypertension},
title = {Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects},
doi = {10.3390/ijerph182413047},
author = {Haverinen, Elsi and Fernández Cabrera, Mariana Fátima and Mustieles Miralles, Vicente},
}