@misc{10481/72538,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/72538},
abstract = {A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)(2)] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against A beta-induced toxicity in the Caenorhabditis elegans model, which has never been reported.},
organization = {Spanish Government	PGC2018-102052-B-C21	
PID2020-116460RB-I00},
organization = {Junta de Andalucia	FQM-394	
FQM-134},
organization = {FEDER/Junta de Andaluci'a Consejeri'a de Economi'a y Conocimiento	B-AGR-193-UGR18},
organization = {MCIN/AEI/	PID2020-116460RB-I00},
organization = {Juan de la Cierva Fellowship	IJC2019-038894-I},
publisher = {Royal Society of Chemistry},
title = {A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A beta-induced toxicity in C. elegans},
doi = {10.1039/d1cc04404d},
author = {García García, Amalia and Rojas Macías, Sara and Rivas García, Lorenzo and Navarro Hortal, María Dolores and Romero Márquez, José Manuel and Choquesillo Lazarte, Duane and Salinas Castillo, Alfonso and Quiles Morales, José Luis and Rodríguez Diéguez, Antonio},
}