@misc{10481/72313,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/72313},
abstract = {The genetic make-up of an individual contributes to the susceptibility and response to
viral infection. Although environmental, clinical and social factors have a role in the
chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may
also be important. Identifying host-specific genetic factors may reveal biological
mechanisms of therapeutic relevance and clarify causal relationships of modifiable
environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a
global network of researchers to investigate the role of human genetics in SARS-CoV-2
infection and COVID-19 severity. Here we describe the results of three genome-wide
association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46
studies across 19 countries. We report 13 genome-wide significant loci that are
associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of
these loci correspond to previously documented associations to lung or autoimmune
and inflammatory diseases3–7. They also represent potentially actionable mechanisms
in response to infection. Mendelian randomization analyses support a causal role for
smoking and body-mass index for severe COVID-19 although not for type II diabetes.
The identification of novel host genetic factors associated with COVID-19 was made
possible by the community of human genetics researchers coming together to
prioritize the sharing of data, results, resources and analytical frameworks. This
working model of international collaboration underscores what is possible for future
genetic discoveries in emerging pandemics, or indeed for any complex human
disease.},
publisher = {Nature},
title = {Mapping the human genetic architecture of COVID-19},
doi = {10.1038/s41586-021-03767-x},
author = {Niemi, Mari E. K. and Carnero Montoro, Elena and García García, Federico and Salazar, Adolfo de and Martín Ibáñez, Javier and Hernández Quero, José and Acosta Herrera, Marialbert and Chueca Porcuna, Natalia and González Cejudo, Trinidad and Alarcón Riquelme, Marta Eugenia and Martínez Bueno, Manuel and The COVID-19 Host Genetics Initiative and 23andMe COVID-19 Team and Norwegian SARS-CoV-2 Study Grp and Humanitas COVID-19 Task Force and Humanitas Gavazzeni COVID-19 Task and FHoGID and RegCOVID and P-PredictUs and SeroCOVID and CRiPSI and Genes & Hlth Res Team and UCLA Hlth ATLAS Data Mart Working},
}