@misc{10481/72271,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/72271},
abstract = {Objective: Omega-6
and omega-3
oxylipins are known to play a role in inflammation
and cardiometabolic diseases in preclinical models. The associations between plasma
levels of omega-6
and omega-3
polyunsaturated fatty acid–derived
oxylipins and
body composition and cardiometabolic risk factors in young adults were assessed.
Methods: Body composition, brown adipose tissue, traditional serum cardiometabolic
risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133
young adults (age 22.1[SD 2.2] years, 67% women).
Results: Plasma levels of four omega-6
oxylipins (15-HeTrE,
5-HETE,
14,15-EpETrE,
and the oxidative stress–derived
8,12-iso-
iPF2α
-VI)
correlated positively with adiposity,
prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment
of insulin resistance index and lipid parameters. By contrast, the plasma levels
of three omega-3
oxylipins (14,15-DiHETE,
17,18-DiHETE,
and 19,20-DiHDPA)
were
negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver
index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory
markers such as interferon gamma or tumor necrosis factor-alpha.
Pathway analyses
revealed that individuals with obesity had higher plasma levels of omega-6
and lower
plasma levels of omega-3
oxylipins than normal-weight
individuals.
Conclusion: Plasma levels of seven omega-6
and omega-3
oxylipins may have utility
as early markers of cardiometabolic risk in young adults.},
organization = {Spanish Government	PI13/01393},
organization = {Retos de la Sociedad	DEP2016-79512-R},
organization = {European Commission		
Spanish Government	FPU16/02828	
FPU19/01609},
organization = {Fundacion Iberoamericana de Nutricion (FINUT)},
organization = {Redes Tematicas de Investigacion Cooperativa RETIC	Red SAMID RD16/0022},
organization = {AstraZeneca},
organization = {University of Granada Plan Propio de Investigacion Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Junta de Andalucia		
Consejeria de Conocimiento, Investigacion y Universidades (ERDF)	SOMM17/6107/UGR	
DOC 01151},
organization = {Fundacion Alfonso Martin Escudero},
organization = {Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation},
organization = {Dutch Federation of University Medical Centers},
organization = {Netherlands Organization for Health Research and Development},
organization = {Royal Netherlands Academy of Sciences	CVON2017-20 GENIUS-2},
organization = {China Scholarship Council	201707060012	
PTA-12264},
publisher = {Wiley-Blackwell Publishing},
title = {Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults},
doi = {10.1002/oby.23282},
author = {Jurado Fasoli, Lucas and Osuna Prieto, Francisco Javier and García Lario, José Vicente and Ruiz Ruiz, Jonatan and Martínez Téllez, Borja Manuel},
}