@misc{10481/72224,
year = {2021},
month = {11},
url = {http://hdl.handle.net/10481/72224},
abstract = {We have investigated the co-self-assembly, in water and at room temperature, of different aromatic short
peptides containing Fmoc- (fluorenylmethyloxycarbonyl-) and Nap- (2-(naphthalen-2-yloxy)acetyl)
groups having also different chirality. Using a combination of spectroscopy and microscopy techniques
we have shown that mixtures of peptides have a stronger preference to form co-assemblies giving rise to
different types of fibrils of well-defined morphology. Kinetic analysis of fluorescence resonance energy
transfer (FRET) between Fmoc- and Nap- side groups reported more information about the process of
self-assembly between different dipeptides. We have shown that when peptides are mixed in an equimolar
ratio, the kinetics of co-aggregation is faster than that occurring when the proportion is unbalanced.
Moreover, following the emission band of Nap-excimers we have shown that these peptides form
co-assemblies in an alternate fashion at an equimolar ratio. The mechanism of self-assembly has been
studied by molecular dynamics and monitored by differential scanning calorimetry. The mechanical properties
of the resulting composite hydrogels have been evaluated by rheology. These results show that
the formation of co-assemblies is promoted by π–π interactions between the different aromatic groups
resulting in accelerating polymerization due to destabilization of the intermediates.},
organization = {MCIN/AEI, Spain	PID2020-118498GB-I00
FPU17/00491},
organization = {MCIN/AEI/FEDER "Una manera de hacer Europa", Spain	CTQ2017-85658-R},
organization = {FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Spain)	P18-FR-3533},
organization = {FSE "El FSE invierte en tu futuro", Spain	PRE2018083773},
organization = {Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion grant},
publisher = {Royal Society of Chemistry},
title = {Insights into the co-assemblies formed by different aromatic short-peptide amphiphiles},
doi = {10.1039/d1py01366a},
author = {Gila Vilchez, Cristina and Mañas Torres, María del Carmen and González Vera, Juan Antonio and Franco Montalbán, Francisco and Tamayo Torres, Juan Antonio and Conejero Lara, Francisco and Cuerva Carvajal, Juan Manuel and López López, Modesto Torcuato and Orte Gutiérrez, Ángel and Álvarez Cienfuegos Rodríguez, Luis},
}