@misc{10481/72148,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/72148},
abstract = {Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to
cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones,
we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite
(acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine,
phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).
Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional
analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as
controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition
cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with
42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant
associations were evaluated in a validation set (n = 786).
Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:
2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and
saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively
associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively
associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors
examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive
association with age was observed. Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and
anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle
correlates of the metabolites investigated.},
organization = {Institut National du Cancer (INCA) France	2015-166},
organization = {International Agency for Research on Cancer - Fondation ARC},
organization = {World Health Organization},
organization = {Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London},
organization = {Danish Cancer Society},
organization = {Ligue Contre le Cancer (France)},
organization = {Institut Gustave Roussy (France)},
organization = {Mutuelle Generale de l'Education Nationale (France)},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe},
organization = {German Cancer Research Center (DKFZ) (Germany)},
organization = {German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany)},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Compagnia di San Paolo},
organization = {Consiglio Nazionale delle Ricerche (CNR)},
organization = {Netherlands Government},
organization = {World Cancer Research Fund International (WCRF)},
organization = {Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain)},
organization = {Junta de Andalucia},
organization = {Regional Government of Asturias (Spain)},
organization = {Regional Government of Basque Country (Spain)},
organization = {Regional Government of Murcia (Spain)},
organization = {Regional Government of Navarra (Spain)},
organization = {Catalan Institute of Oncology-ICO (Spain)},
organization = {Swedish Cancer Society},
organization = {Swedish Research Council},
organization = {County Council of Skane (Sweden)},
organization = {County Council of Vasterbotten (Sweden)},
organization = {Cancer Research UK	14136	
C8221/A29017},
organization = {UK Research & Innovation (UKRI)},
organization = {Medical Research Council UK (MRC)	1000143	
MR/N003284/1	
MC-UU_12015/1	
MC_UU_00006/1	
MR/M012190/1},
publisher = {BMC},
keywords = {Metabolites},
keywords = {Breast cancer},
keywords = {Cross-sectional},
keywords = {Lifestyle},
keywords = {Anthropometry},
title = {Lifestyle correlates of eight breast cancerrelated metabolites: a cross-sectional study within the EPIC cohort},
doi = {10.1186/s12916-021-02183-2},
author = {His, Mathilde and Sánchez Pérez, María José},
}