@misc{10481/71695,
year = {2021},
url = {http://hdl.handle.net/10481/71695},
abstract = {Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped
polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and
brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs,
(3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne®. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA
and Student–Newman–Keuls tests were used (p < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex
modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped
NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne® have around
30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped
NPs, but in the case of specimens treated with Sensodyne®, complex modulus values were reduced
below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced
acid-resistant tubular occlusion and increased the mechanical properties of dentin.},
organization = {Ministry of Economy and Competitiveness (MINECO) and European Regional Development Fund (FEDER), grant number PID2020-114694RB-I00 MINECO/AEI/
FEDER/UE},
organization = {Laboratorios KIN® fabricated and provided tested experimental pastes loaded with
Zn-doped NPs},
publisher = {MDPI},
keywords = {Nanoparticles},
keywords = {Zinc},
keywords = {Dentin hypersensitivity},
keywords = {Dentinal tubules},
keywords = {Dentifrice},
title = {Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study},
doi = {10.3390/nano11113150},
author = {Toledano Osorio, Manuel and Osorio Ruiz, Raquel and Osorio Ruiz, María Estrella and Medina Castillo, Antonio Luis and Toledano Pérez, Manuel},
}