@misc{10481/71690,
year = {2021},
month = {10},
url = {http://hdl.handle.net/10481/71690},
abstract = {A general imbalance in the proportion of disembarked males and females in the Americas
has been documented during the Trans-Atlantic Slave Trade and the Colonial Era and, although less
prominent, more recently. This imbalance may have left a signature on the genomes of modern-day
populations characterised by high levels of admixture. The analysis of the uniparental systems
and the evaluation of continental proportion ratio of autosomal and X chromosomes revealed a
general sex imbalance towards males for European and females for African and Indigenous American
ancestries. However, the consistency and degree of this imbalance are variable, suggesting that other
factors, such as cultural and social practices, may have played a role in shaping it. Moreover, very
few investigations have evaluated the sex imbalance using haplotype data, containing more critical
information than genotypes. Here, we analysed genome-wide data for more than 5000 admixed
American individuals to assess the presence, direction and magnitude of sex-biased admixture in
the Americas. For this purpose, we applied two haplotype-based approaches, ELAI and NNLS, and
we compared them with a genotype-based method, ADMIXTURE. In doing so, besides a general
agreement between methods, we unravelled that the post-colonial admixture dynamics show higher
complexity than previously described.},
organization = {European Commission	2014-2020.4.01.16-0030	
2014-2020.4.01.16-0271	
2014-2020.4.01.16-0125	
2014-2020.4.01.16-0024	
2014-2020.4.01.15-0012},
organization = {MOBEC008},
organization = {Estonian Research Council grant PUT	PRG243	
PRG1027},
organization = {European Commission	810645	
824110},
organization = {Ministry of Education, Universities and Research (MIUR)	PRIN2017 20174BTC4R},
publisher = {MDPI},
keywords = {Admixture},
keywords = {American populations},
keywords = {Sex-biased imbalance},
keywords = {Haplotypes},
keywords = {Human migrations},
title = {Evaluating the Impact of Sex-Biased Genetic Admixture in the Americas through the Analysis of Haplotype Data},
doi = {10.3390/genes12101580},
author = {Ongaro, Linda and Alarcón Riquelme, Marta Eugenia},
}