@misc{10481/71687,
year = {2021},
url = {http://hdl.handle.net/10481/71687},
abstract = {Although it is known that textile wastewater contains highly toxic contaminants whose
effects in humans represent public health problems in several countries, studies involving mammal
species are scarce. This study was aimed to evaluate the toxicity profile of 90-days oral administration
of textile dyeing effluent (TDE) on oxidative stress status and histological changes of male mice. The
TDE was collected from the textile plant of Monastir, Tunisia and evaluated for the metals, aromatic
amines, and textile dyes using analytical approaches. Metal analysis by ICP-MS showed that the
tested TDE exhibited very high levels of Cr, As, and Sr, which exceeded the wastewater emission
limits prescribed by WHO and Tunisian authority. The screening of TDE through UPLC-MS/MS
confirmed the presence of two textile dyes: a triphenylmethane dye (Crystal violet) and a disperse
azo dye (Disperse yellow 3). Exposure to TDE significantly altered the malondialdehyde (MDA),
Conjugated dienes (CDs), Sulfhydryl proteins (SHP) and catalase levels in the hepatic and renal
tissues. Furthermore, histopathology observation showed that hepatocellular and renal lesions
were induced by TDE exposure. The present study concluded that TDE may involve induction
of oxidative stress which ensues in pathological lesions in several vital organs suggesting its high
toxicity. Metals and textile dyes may be associated with the observed toxicological effects of the TDE.
These pollutants, which may have seeped into surrounding rivers in Monastir city, can cause severe
health malaise in wildlife and humans.},
organization = {Ministry of Higher Education and
Scientific Research in Tunisia},
publisher = {MDPI},
keywords = {Textile dyeing effluent},
keywords = {Mice},
keywords = {Oxidative stress},
keywords = {Histopathology},
keywords = {Metals},
keywords = {Toxicity},
title = {Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice},
doi = {10.3390/ijms222212568},
author = {Methneni, Nosra and Ezdini, Khawla and Ben Abdeljelil, Nouha and Van Loco, Joris and Van den Houwe, Kathy and Jabeur, Riheb and Fekih Sallem, Ons and Jaziri, Ahlem and Fernández Serrano, Mercedes and Khdary, Nezar H. and Ben Mansour, Hedi},
}