@misc{10481/71408,
year = {2021},
month = {10},
url = {http://hdl.handle.net/10481/71408},
abstract = {Leishmaniasis and Chagas diseases are two of the most
important parasitic diseases in the world. Both belong to the
category of Neglected Tropical Diseases, and they cannot be
prevented by vaccination. Their treatments are founded in
outdated drugs that possess many pernicious side-effects and
they’re not easy to administer. With the aim of discovering new
compounds that could serve as anti-trypanosomal drugs, an
antiparasitic study of a synthetic compound family has been
conducted. A series of new 1,4-bis(alkylamino)- and 1-
alkylamino-4-chloroazine and benzoazine derivatives 1–4 containing
imidazole rings have been synthesized and identified.
Their structures showed a possible interest based on previous
work. Their in vitro anti-Leishmania infantum, anti-L. braziliensis,
anti-L. donovani and anti-T. cruzi activity were tested, as well as
the inhibition of Fe-SOD enzymes. It was found that some of
them exhibited quite relevant values indicative of being worthy
of future more detailed studies, as most of them showed
activity to more than only one parasite species, especially
compound 3c was active for the three studied Leishmania
species and also for T. cruzi, which is a very interesting trait as it
covers a wide spectrum.},
organization = {MCINN Project	CTQ2009-14288-C04-01},
publisher = {Wiley-VCH Verlag GmbH},
keywords = {Azines and benzoazines},
keywords = {Imidazole},
keywords = {In vitro trypanosomicidal and leishmanicidal activity},
keywords = {Fe-SOD inhibition},
title = {In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives},
doi = {10.1002/cmdc.202100413},
author = {Martín Montes, Álvaro Miguel and Marín Sánchez, Clotilde and Rosales Lombardo, María José and Sánchez Moreno, Manuel},
}