@misc{10481/71338,
year = {2021},
url = {http://hdl.handle.net/10481/71338},
abstract = {Melatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or
Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and
omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male
Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with
melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not
significantly influenced by diabesity in the analyzed tissues (p > 0.05), with the exception of Zn in
liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly
with melatonin supplementation in ZDF rats (p < 0.05). This cytoplasmic Zn enhancement would
be probably associated with the upregulation of several Zn influx membrane transporters (Zips)
and could explain the amelioration in the glycaemia and insulinaemia by upregulating the Akt and
downregulating the inhibitor PTP1B, in obese and diabetic conditions. Enhanced Zn and Cu levels in
muscle cells could be related to the reported antioxidant melatonin activity exerted by increasing the
Zn, Cu-SOD, and extracellular Cu-SOD activity. In conclusion, melatonin, by increasing the muscle
levels of Zn and Cu, joined with our previously reported findings improves glycaemia, insulinaemia,
and oxidative stress in this diabesity animal model.},
organization = {SAF2016-79794-R from the Ministerio de Economía y
Competitividad (Spain) and European Regional Development Fund (ERDF).},
publisher = {MDPI},
keywords = {Melatonin},
keywords = {Zinc},
keywords = {Copper},
keywords = {Diabetic obese rat},
title = {Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats},
doi = {10.3390/pharmaceutics13101535},
author = {Navarro Alarcón, Miguel and Gil Hernández, Fernando and Sánchez González, Cristina and Llopis González, Juan and Villalón Mir, Marina and Olmedo Palma, Pablo and Alarcón Guijo, Pablo and Salagre Simón, Diego and Gaona, Lorena and Paredes, Mario and Agil Abdalla, Mhmad Ahmad},
}