@misc{10481/71289,
year = {2021},
url = {http://hdl.handle.net/10481/71289},
abstract = {Vitamin D has been associated with risk, development, and progression of cancer. However,
the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of
this study is to evaluate the association between the gene polymorphisms involved in the metabolic
pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study
was designed as an observational cohort which included 194 Caucasians patients from southern Spain
with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms:
CYP27B1 rs4646536, rs3782130, and rs10877012; CYP24A1 rs6068816 and rs4809957; GC rs7041;
CYP2R1 rs10741657; VDR rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI),
and rs731236 (TaqI). Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (p = 0.0233) and in the
non-resected NSCLC subgroup (p = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (p = 0.0129) and rs7041 with PFS (p = 0.0447). In the non-resected NSCLC subgroup,
rs6068816 was associated with PFS (p = 0.0048) and OS (p = 0.0089) and rs731236 and rs7975232
were associated with OS (p = 0.0005) and PFS (p = 0.0002), respectively. The other polymorphisms
showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232
polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic
markers of the disease},
organization = {ERDF funds (EU)},
organization = {Virgen de las Nieves University Hospital Biobank},
organization = {Instituto de Salud Carlos III (PT13/0010/0039)},
publisher = {MDPI},
keywords = {Vitamin D metabolism},
keywords = {Survival},
keywords = {Non-small-cell lung cancer},
keywords = {Single nucleotide polymorphism},
keywords = {CYP27B1},
keywords = {CYP24A1},
keywords = {CYP2R1},
keywords = {GC},
keywords = {VDR},
title = {Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer},
doi = {10.3390/nu13113783},
author = {Pineda Lancheros, Laura Elena and Pérez Ramírez, Cristina and Sánchez Martín, Almudena and Gálvez Navas, José María and Martínez Martínez, Fernando and Ramírez Tortosa, María Carmen and Jiménez Morales, Alberto},
}