@misc{10481/71237,
year = {2021},
month = {10},
url = {http://hdl.handle.net/10481/71237},
abstract = {Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study
aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of
antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the
effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model
Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and
pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of
strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein
induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular
mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and
SKN-1/NRF2 signaling pathways were, at least partially, involved.},
organization = {Universidad de Granada/CBUA},
publisher = {Elsevier},
keywords = {Berries},
keywords = {Antioxidants},
keywords = {Anthocyanins},
keywords = {Minerals},
keywords = {RNAi},
keywords = {ROS},
title = {Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans},
doi = {10.1016/j.foodchem.2021.131272},
author = {Navarro Hortal, María Dolores and Romero Márquez, José Manuel and Esteban Muñoz, Adelaida and Sánchez González, Cristina and Rivas García, Lorenzo and Llopis González, Juan and Quiles Morales, José Luis},
}