@misc{10481/71111,
year = {2021},
month = {9},
url = {http://hdl.handle.net/10481/71111},
abstract = {Oral minoxidil is an approved treatment for high blood pressure which is also used as
an off-label drug for alopecia. Knowledge about the effects of systemic minoxidil in the paediatric
population is limited. A retrospective case series study of paediatric patients with history of systemic
minoxidil intake due to contaminated sets of omeprazole was performed to describe side effects of
high dose oral minoxidil intake in children. Twenty patients aged between 2 months and 13 years
joined the study. They had received high doses of oral minoxidil (mean dose 0.90 mg/kg/day)
during a mean time of 38.3 days. Hypertrichosis appeared in 65%, with a mean latency time of
24.31 days. Treatment time was associated with the appearance of hypertrichosis (p < 0.05). Most
common initial zone of hypertrichosis was the face. Systemic effects developed in 15%, with no cases
of severe disorders. The present study shows a novel insight into the side effects of high doses of oral
minoxidil in children.},
publisher = {MDPI},
keywords = {Minoxidil},
keywords = {Hypertrichosis},
keywords = {Alopecia},
keywords = {Children},
title = {Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects},
doi = {10.3390/jcm10184257},
author = {Sánchez Diaz, Manuel and López Delgado, David and Montero Vílchez, Trinidad and Salvador Rodríguez, Luis and Molina Leyva, Alejandro and Tercedor Sánchez, Jesús and Arias Santiago, Salvador Antonio},
}