@misc{10481/71013, year = {2021}, url = {http://hdl.handle.net/10481/71013}, abstract = {Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as a component of functional foods for the prevention of metabolic syndrome, due to its anti-inflammatory activity. We analyzed the effects of OA on inflammatory parameters and signaling proteins in LPS-stimulated THP-1 macrophages. Thus, THP-1 macrophages were incubated with LPS for 48 h after pretreatment with OA at different concentrations. Pretreatment with OA was significantly effective in attenuating IL-6 and TNF-α overproduction induced by LPS in macrophages, and also improved the levels of AMPK-α. We also evaluated the effects of human triglyceride-rich lipoproteins (TRLs) derived from individuals consuming an OA-enriched functional olive oil. For this purpose, TRLs were isolated from healthy adolescents before, 2 and 5 h postprandially after the intake of a meal containing the functional olive oil or common olive oil, and were incubated with THP-1 macrophages. THP-1 macrophages incubated with TRLs isolated at 2 h after the consumption of the OA-enriched olive oil showed significant lower levels of IL-6 compared to the TRLs derived from olive oil. Our results suggest that OA might have potential to be used as a lipid-based formulation in functional olive oils to prevent inflammatory processes underlying metabolic syndrome in adolescents.}, organization = {Andalusia 2014–2020 European Regional Development Fund (ERDF) Operative Program, grant number B-AGR-287-UGR18.}, publisher = {MDPI}, keywords = {Oleanolic acid}, keywords = {Olive oil}, keywords = {Functional foods}, keywords = {Postprandial trial}, keywords = {Human triglyceride-rich lipoproteins}, keywords = {Metabolic syndrome}, keywords = {Obesity}, keywords = {Insuline resistance}, keywords = {Adolescents}, keywords = {THP-1 macrophages}, title = {Oleanolic Acid-Enriched Olive Oil Alleviates the Interleukin-6 Overproduction Induced by Postprandial Triglyceride-Rich Lipoproteins in THP-1 Macrophages}, doi = {10.3390/nu13103471}, author = {Fernández Aparicio, Ángel and Correa Rodríguez, María and Schmidt RioValle, Jacqueline and González Jiménez, Emilio}, }