@misc{10481/71008,
year = {2021},
url = {http://hdl.handle.net/10481/71008},
abstract = {Previous experiments in animals and humans show that shifts in microbiota and its
metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX,
a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and
attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model
of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt
hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure,
improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX
decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier
integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta.
These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial
effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase
in blood pressure in this low-renin form of hypertension.},
organization = {Grants from Comisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad (SAF2017-84894-R)},
organization = {Ministerio de Ciencia e
Innovación (PID2020-116347RB-I00)},
organization = {Junta de Andalucía (CTS-164, P20_00193)},
organization = {European Union, and by the Ministerio de Economia y Competitividad, Instituto de Salud Carlos III
(CIBER-CV; Ciberes)},
organization = {Instituto de Salud Carlos III (Sara Borrell
Program)},
organization = {European Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una
manera de hacer Europa”)},
publisher = {MDPI},
keywords = {Doxycycline},
keywords = {Gut dysbiosis},
keywords = {Hypertension},
keywords = {Oxidative stress},
keywords = {Inflammation},
keywords = {(Deoxycorticosterone acetate) DOCA-salt model},
title = {Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats},
doi = {10.3390/nu13092971},
author = {Robles Vera, Iñaki and de la Visitación, Néstor and Toral, Marta and Sánchez Santos, Manuel and Romero Pérez, Miguel and Gómez Guzmán, Manuel and Vargas Palomares, José Félix and Duarte Pérez, Juan Manuel and Jiménez Moleón, Rosario},
}