@misc{10481/70935,
year = {2021},
month = {9},
url = {http://hdl.handle.net/10481/70935},
abstract = {Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder affecting the gastrointes-tinal tract. The pharmacological treatments used currently for its treatment lack efficacy, so new therapeutic strategies should be developed. In this context, flavonoids loaded in biopolymeric nanoparticles can be considered as novel promising candidates. The aim of the present study was to evaluate the intestinal anti-inflammatory effects of quercetin when is administered loaded in silk fibroin nanoparticles (QSFN) in the dextran sulphate sodium experimental model of mouse colitis, which displays some similarities to human IBD. Previously characterized quercetin-loaded silk fibroin nanoparticles (QSFN). QSFN showed a reversible aggre-gation profile induced by the acidification of the solution but did not affect the loaded quercetin. Daily administration of QSFN significantly reduced disease activity index values compared to the control colitic group. This beneficial effect was not only corroborated by the histological examination of the colonic specimens but also the improvement of the colonic expression of the different proinflammatory cytokines (Tnf-alpha, Il-1 beta, Il-6, Mcp-1, Icam-1, Nlrp3 and iNOS). Therefore, these data suggest that QSFN could be a promising alternative to current treatments as a drug delivery system for IBD treatment.},
organization = {European Commission ERDF/FEDER Operational Programme `Murcia' CCI	2007ES161PO001- 14-20/20},
organization = {Junta de Andalucia	CTS164},
organization = {Instituto de Salud Carlos III
European Commission	PI19/01058},
organization = {Spanish MINECO	CTQ201787708-R},
organization = {ERDF/FEDER Operational Programme 'Murcia' CCI	2007ES161PO001- 14-20/20},
publisher = {Elsevier},
keywords = {Inflammatory bowel disease},
keywords = {Silk fibroin nanoparticles},
keywords = {Quercetin},
keywords = {Anti-inflammatory},
keywords = {Drug loading},
title = {Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis},
doi = {10.1016/j.ijpharm.2021.120935},
author = {Díez Echave, Patricia and Ruiz Malagón, Antonio Jesús and Molina Tijeras, José Alberto and Hidalgo García, Laura and Vezza, Teresa and Cenis Cifuentes, Laura and Rodríguez Sojo, María Jesús and Cenis, José Luis and Rodríguez Cabezas, María Elena and Rodríguez Nogales, Alba and Gálvez Peralta, Julio Juan and Lozano-Pérez, Antonio Abel},
}