@misc{10481/70865,
year = {2021},
month = {9},
url = {http://hdl.handle.net/10481/70865},
abstract = {Collagen membranes are currently the most widely used membranes for guided bone regeneration;
however, their rapid degradation kinetics means that the barrier function may not remain for
enough time to permit tissue regeneration to happen. The origin of collagen may have an important
effect on the resistance to degradation. The aim of this study was to investigate the biodegradation
pattern of five collagen membranes from different origins: Biocollagen, Heart, Evolution X-fine, CopiOs
and Parasorb Resodont. Membranes samples were submitted to different degradation tests: (1)
hydrolytic degradation in phosphate buffer saline solution, (2) bacterial collagenase from Clostridium
histolyticum solution, and (3) enzyme resistance using a 0.25% porcine trypsin solution. Immersion
periods from 1 up to 50 days were performed. At each time point, thickness and weight measurements
were performed with a digital caliper and an analytic microbalance, respectively. ANOVA and
Student–Newman–Keuls tests were used for comparisons (p < 0.05). Differences between time-points
within the same membranes and solutions were assessed by pair-wise comparisons (p < 0.001). The
Evolution X-fine collagen membrane from porcine pericardium attained the highest resistance to all
of the degradation tests. Biocollagen and Parasorb Resodont, both from equine origin, experienced
the greatest degradation when immersed in PBS, trypsin and C. histolyticum during challenge tests.
The bacterial collagenase solution was shown to be the most aggressive testing method.},
organization = {Ministry of Economy and Competitiveness	PID2020-114694RB-100},
organization = {European Commission	PID2020-114694RB-100	
A-BIO-157-UGR-18/FEDER},
organization = {University of Granada/Regional Government of Andalusia Research Fund from Spain	A-BIO-157-UGR-18/FEDER},
publisher = {MDPI},
keywords = {Bone regeneration},
keywords = {Collagen membrane},
keywords = {Hydrolytic degradation},
keywords = {Collagen origin},
keywords = {Bacterial collagenase},
keywords = {Trypsin digestion},
keywords = {Degradation testing},
keywords = {Degradation kinetics},
title = {The Collagen Origin Influences the Degradation Kinetics of Guided Bone Regeneration Membranes},
doi = {10.3390/polym13173007},
author = {Vallecillo Rivas, Marta and Toledano Osorio, Manuel and Vallecillo, Cristina and Toledano Pérez, Manuel and Osorio Ruiz, Raquel},
}