@misc{10481/70749,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/70749},
abstract = {Objectives We present this systematic review and meta-analyses to evaluate current evidence on the prevalence of depression,
anxiety, and stress in patients with oral lichen planus and their magnitude of association.
Material and methods We searched PubMed, Embase, Web of Science, Scopus, PsycInfo, and Google Scholar for studies
published before January 2021. We evaluated the quality of studies using a specific method for systematic reviews addressing
prevalence questions, designed by the Joanna Briggs Institute. We carried out meta-analyses and performed heterogeneity,
subgroups, meta-regression, and small-study effects analyses.
Results Fifty-one studies (which recruited 6,815 patients) met the inclusion criteria. Our results reveal a high prevalence
of depression (31.19%), anxiety (54.76%), and stress (41.10%) in oral lichen planus. Furthermore, OLP patients presented
a significantly higher relative frequency than control group without OLP for depression (OR = 6.15, 95% CI = 2.73–13.89,
p < 0.001), anxiety (OR = 3.51, 95% CI = 2.10–5.85, p < 0.001), and stress (OR = 3.64, 95% CI = 1.48–8.94, p = 0.005), showing
large effect sizes. Subgroups meta-analyses showed the relevance of the participation of psychologists and psychiatrists
in the diagnosis of depression, anxiety, and stress in patients with OLP. Multivariable meta-regression analysis showed the
importance of the comorbidity of depression-anxiety in patients with OLP.
Conclusions Our systematic review and meta-analysis show that patients with OLP suffer a higher prevalence of depression,
anxiety, and stress, being more frequent than in general population.
Clinical relevance
In the dental clinic, especially dentists should be aware of depression, anxiety, and stress in OLP patients to achieve a correct
referral.},
organization = {Universidad de Granada/CBUA},
publisher = {Springer},
keywords = {Oral lichen planus},
keywords = {Depression},
keywords = {Anxiety},
keywords = {Stress},
keywords = {Systematic review},
keywords = {Meta-analysis},
title = {Depression, anxiety, and stress in oral lichen planus: a systematic review and meta‑analysis},
doi = {10.1007/s00784-021-04114-0},
author = {De Porras Carrique, Teresa and González Moles, Miguel Ángel and Ramos García, Pablo},
}