@misc{10481/70728,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/70728},
abstract = {Recently, mineral healing clays have gained much attention for wound-dressing applications.
Here, we selected halloysite (HAL) clay as a biocompatible, non-toxic material that is useful
as a drug delivery system to enhance the healing properties of water-soluble terpenoids 1-3 (T1-3).
Terpenoids-loaded HAL clay (TH1-3) was prepared and characterized by adsorption equilibrium
studies, X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), differential scanning
calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy, and release studies. The results
reveal that T1-3 were adsorbed at the HAL surface with good efficiency. The prevalent mechanism
of drug retention is due to the adsorption via electrostatic interactions between the cationic groups
of the T1-3 and the HAL’s external surface. Release studies demonstrated that T3 was released
in a higher percentage (>60%) compared to T1-2 ( 50%). Additionally, TH1-3 were assessed for
their antimicrobial activity and capability to promote the re-epithelialization of scratched HaCat
monolayers, through the time-kill test and the wound-healing assays, respectively. The results reveal
that all the tested formulations were able to reduce the microbial growth after 1 h of incubation and
that they ensured complete wound closure after 48 h. Furthermore, at the concentration of 1  g/mL,
TH3 exhibited 45% wound closure at 24 h, compared to TH1 (27%) and TH2 (30%), proving to be the
best candidate in making the tissue-repair process easier and faster.},
organization = {Italian Ministry of Education, University and Research (University "G. d'Annunzio" of Chieti-Pescara)	FAR 2020},
publisher = {MDPI},
keywords = {Clay},
keywords = {Halloysite},
keywords = {Skin regeneration},
keywords = {Terpenoids},
keywords = {Wound healing},
title = {In Vitro Wound-Healing Properties of Water-Soluble Terpenoids Loaded on Halloysite Clay},
doi = {10.3390/pharmaceutics13081117},
author = {Marinelli, Lisa and Borrego Sánchez, Ana María and García Villén, Fátima and Viseras Iborra, César Antonio},
}