@misc{10481/70651,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/70651},
abstract = {The aim of this study was to systematically review all evidence evaluating obesity as a prognostic factor for PC mortality. Cohort and case-control studies reporting mortality among PC patients stratified by body mass index (BMI) were included. The risk of mortality among obese patients (BMI >= 30) was compared with the risk for normal weight (BMI < 25) patients, pooling individual hazard ratios (HR) in random-effects meta-analyses. Reasons for heterogeneity were assessed in subgroup analyses. Dose-response associations for BMI per 5 kg/m(2) change were assessed. Among 7278 citations, 59 studies (280,199 patients) met inclusion criteria. Obesity was associated with increased PC-specific mortality (HR: 1.19, 95% CI: 1.10-1.28, I-2: 44.4%) and all-cause mortality (HR: 1.09, 95% CI: 1.00-1.18, I-2: 43.9%). There was a 9% increase (95% CI: 5-12%, I-2: 39.4%) in PC-specific mortality and 3% increase (95% CI: 1-5%, I-2: 24.3%) in all-cause mortality per 5 kg/m(2) increase in BMI. In analyses restricted to the higher quality subgroup (NOS >= 8), obesity was associated with increased PC-specific mortality (HR: 1.24, 95% CI: 1.14-1.35, I-2: 0.0%) and maintained the dose-response relationship (HR: 1.11 per 5 kg/m(2) increase in BMI, 95% CI: 1.07-1.15, I-2: 26.6%). Obesity had a moderate, consistent, temporal, and dose-response association with PC mortality. Weight control programs may have a role in improving PC survival.},
organization = {Ministry of Science, Innovation, and Universities of the Spanish Government},
publisher = {MDPI},
keywords = {Body mass index},
keywords = {Prostate cancer specific mortality},
keywords = {All-cause mortality},
keywords = {Outcomes},
keywords = {Causation},
title = {Obesity as a Risk Factor for Prostate Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of 280,199 Patients},
doi = {10.3390/cancers13164169},
author = {Rivera Izquierdo, Mario and Pérez de Rojas, Javier and Martínez Ruiz, Virginia Ana and Sánchez Pérez, María José and Saeed Khan, Khalid and Jiménez Moleón, José Juan},
}