@misc{10481/70642,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/70642},
abstract = {Despite some epidemiological evidence on the protective effects of polyphenol intake on
epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective
studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the
associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a
large prospective study. The study was conducted in the European Prospective Investigation into
Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from
the general population. Polyphenol intake was assessed through validated country-specific dietary
questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first
incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours)
were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest
quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI
0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were
not related to either overall EOC risk or any EOC subtype. A borderline statistically significant
positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43;
p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although
these associations did not exceed the Bonferroni correction threshold. The current results do not
support any association between polyphenol intake and EOC in our large European prospective
study. Results regarding phenolic acid intake need further investigation},
organization = {Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht},
organization = {National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands},
organization = {Public Health Directorate, Asturias, Spain},
organization = {Oxford University},
organization = {World Health Organization},
organization = {NIHR Imperial Biomedical Research Centre (BRC)},
organization = {Danish Cancer Society},
organization = {Ligue nationale contre le cancer},
organization = {Institut Gustave Roussy},
organization = {Mutuelle Generale de l'Education Nationale},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe		
Helmholtz Association		
Federal Ministry of Education & Research (BMBF)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Consiglio Nazionale delle Ricerche (CNR)},
organization = {Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds		
Dutch Prevention Funds		
Netherlands Organization for Scientific Research (NWO)		
World Cancer Research Fund (WCRF), Statistics Netherlands},
organization = {Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII)},
organization = {Swedish Cancer Society		
Swedish Research Council},
organization = {European Commission},
organization = {Vasterbotten (Sweden)},
organization = {Cancer Research UK	14136	
C8221/A29017},
organization = {UK Research & Innovation (UKRI)
Medical Research Council UK (MRC)},
organization = {European Commission	1000143	
MR/M012190/1},
organization = {CERCA Program/Generalitat de Catalunya	CPII20/00009	
Instituto de Salud Carlos III},
organization = {European Social Fund (ESF)},
organization = {University of Cambridge},
organization = {Imperial College of London, the UK},
organization = {Women's Health Dexeus Foundation},
publisher = {MDPI},
keywords = {Ovarian cancer},
keywords = {Polyphenols},
keywords = {Flavonoids},
keywords = {Intake},
keywords = {Cohort},
keywords = {EPIC},
title = {Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study},
doi = {10.3390/antiox10081249},
author = {Londoño, Catalina and Sánchez Pérez, María José},
}