@misc{10481/70563, year = {2021}, month = {7}, url = {http://hdl.handle.net/10481/70563}, abstract = {The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.}, publisher = {Frontiers Research Foundation}, keywords = {Advanced therapy}, keywords = {Conditioned medium}, keywords = {Dermatology}, keywords = {Mesenchymal stem cells}, keywords = {Stem cells}, title = {Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review}, doi = {10.3389/fcell.2021.654210}, author = {Montero Vílchez, Trinidad and Sierra Sánchez, Álvaro and Sánchez Diaz, Manuel and Quiñones Vico, María Isabel and Sanabria de la Torre, Raquel and Martínez López, Antonio and Arias Santiago, Salvador Antonio}, }