@misc{10481/70550,
year = {2021},
url = {http://hdl.handle.net/10481/70550},
abstract = {Psoriasis is a major global health problem. There is a need to develop techniques to help
physicians select the most appropriate cost-effective therapy for each patient. The main objectives
of this study are (1) to evaluate changes in epidermal barrier function and skin homeostasis after
phototherapy and (2) to explore potentially predictive values in epidermal barrier function and
skin homeostasis to assess clinical improvement after fifteen sessions of phototherapy. A total
of 76 subjects, 38 patients with plaque-type psoriasis and 38 gender- and age-matched healthy
volunteers, were included in the study. Erythema, transepidermal water loss (TEWL), temperature,
stratum corneum hydration (SCH), pH, sebum, and antioxidant capacity were measured before
and after the first and fifteenth phototherapy session. Erythema (401.09 vs. 291.12 vs. 284.52 AU,
p < 0.001) and TEWL (18.23 vs. 11.44 vs. 11.41 g·m−2
·h
−1
, p < 0.001) were significantly higher at
psoriatic plaques than in uninvolved psoriatic skin and healthy volunteers, respectively, while SCH
was lower (9.71 vs. 44.64 vs. 40.00 AU, p < 0.001). After fifteen phototherapy sessions, TEWL
(–5.19 g·m−2
·h
−1
, p = 0.016) decreased while SCH (+7.01 AU, p = 0.013) and erythema (+30.82 AU,
p = 0.083) increased at psoriatic plaques. An erythema increase exceeding 53.23 AU after the first
phototherapy session, with a sensitivity of 71.4% and specificity of 84.2%, indicates that a patient may
improve Psoriasis Area and Severity Index (PASI) by ≥3 points after fifteen phototherapy sessions. In
conclusion, phototherapy improves epidermal barrier function in psoriatic patients and the erythema
increase after one phototherapy session could help doctors select psoriasis patients who are more
likely to respond to phototherapy.},
publisher = {MDPI},
keywords = {Phototherapy},
keywords = {Psoriasis},
keywords = {Skin barrier},
keywords = {Skin physiology},
keywords = {Skin homeostasis},
title = {Erythema Increase Predicts Psoriasis Improvement after Phototherapy},
doi = {10.3390/jcm10173897},
author = {Montero Vilchez, Trinidad and Martínez López, Antonio and Sierra Sánchez, Álvaro and Soler Góngora, Miguel and Jiménez Mejías, Eladio and Molina Leyva, Alejandro and Buendía Eisman, Agustín and Arias Santiago, Salvador Antonio},
}