@misc{10481/70526,
year = {2021},
url = {http://hdl.handle.net/10481/70526},
abstract = {Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre
study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with
COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted
to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and
clinical data were collected from hospital records. The Kaplan–Meier method was used to estimate
30-day survival and multiple Cox regression models were applied. All analyses were stratified by
sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality
reached 19.1% in men and 16.0% in women. Factors independently associated with an increased
hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment,
in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung
disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital
mortality was higher in men, but the long-term effects of COVID-19 merit further research. The
sex-differential impact of the pandemic should be addressed in public health policies.},
publisher = {MDPI},
keywords = {COVID-19},
keywords = {SARS-CoV-2},
keywords = {Hospital mortality},
keywords = {Risk Factors},
keywords = {Sex},
title = {Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study},
doi = {10.3390/ijerph18179018},
author = {Fernández Martínez, Nicolás Francisco and Rivera Izquierdo, Mario},
}