@misc{10481/70507,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/70507},
abstract = {In the present study, we analyzed the activity of several aminopeptidases (angiotensinases)
involved in the metabolism of various angiotensin peptides, in pituitary and adrenal glands
of untreated Wistar–Kyoto (WKY) and spontaneously hypertensive rats (SHR) or treated with
the antihypertensive drugs captopril and propranolol or with the L-Arginine hypertensive analogue
L-NG-Nitroarginine Methyl Ester (L-NAME). Intra- and inter-gland correlations between
angiotensinase activities were also calculated. Membrane-bound alanyl-, cystinyl-, and glutamylaminopeptidase
activities were determined fluorometrically using aminoacyl- -naphthylamide as
substrates. Depending on the type of angiotensinase analyzed, the results reflect a complex picture
showing substantial differences between glands, strains, and treatments. Alanyl-aminopeptidase
responsible for the metabolism of Ang III to Ang IV appears to be the most active angiotensinase
in both pituitary and adrenals of WKY and particularly in SHR. Independently of treatment, most
positive correlations are observed in the pituitary gland of WKY whereas such positive correlations
are predominant in adrenals of SHR. Negative inter-gland correlations were observed in control SHR
and L-NAME treated WKY. Positive inter-gland correlations were observed in captopril-treated SHR
and propranolol-treated WKY. These results may reflect additional mechanisms for increasing or
decreasing systolic blood pressure in WKY or SHR.},
organization = {Spanish Government	SAF 2008 04685 C02 01},
publisher = {MDPI},
keywords = {Aminopeptidases},
keywords = {Wistar-Kyoto},
keywords = {Spontaneously hypertensive rats},
keywords = {Pituitary},
keywords = {Adrenals},
keywords = {Captopril},
keywords = {Propranolol},
keywords = {L-NAME},
title = {Interaction between Angiotensinase Activities in Pituitary and Adrenal Glands of Wistar–Kyoto and Spontaneously Hypertensive Rats under Hypotensive or Hypertensive Treatments},
doi = {10.3390/ijms22157823},
author = {Segarra, Ana Belén and Prieto, Isabel and Banegas, Inmaculada and Martínez Cañamero, Magdalena and Villarejo, Ana B. and Domínguez Vías, German and Gasparo, Marc de and Ramírez Sánchez, Manuel},
}