@misc{10481/70398,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/70398},
abstract = {Tryptophan catabolism is a major metabolic pathway utilized by several professional and
non-professional antigen presenting cells to maintain immunological tolerance. Here we
report that 3-hydroxy-L-kynurenamine (3-HKA) is a biogenic amine produced via an alternative
pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by
inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic
cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and
cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental
mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring,
reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector
CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing
inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall
ameliorating immune-mediated glomerulonephritis and renal dysfunction. Overall, we propose
that this biogenic amine is a crucial component of tryptophan-mediated
immune tolerance.},
organization = {Swiss National Science Foundation (SNSF)},
organization = {European Commission	310030_182528},
organization = {Fondazione Telethon	GGP17094},
organization = {Fondazione AIRC per la ricerca sul cancro	19903},
organization = {Sigrid Juselius Foundation},
organization = {United States Department of Health & Human Services},
organization = {National Institutes of Health (NIH) - USA	T32 DK007110	
K12 GM102779},
organization = {Fondazione AIRC per la ricerca sul cancro	AIRC 2019-23084},
organization = {United States Department of Health & Human Services},
organization = {National Institutes of Health (NIH) - USA},
organization = {NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)	ZIG AR041181-11},
organization = {European Union H2020 ERA project	667824	
NIH-AG045223	
NIH-AI137198	
NIH-AI103338	
NIH-AI138552},
publisher = {Nature},
title = {3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine},
doi = {10.1038/s41467-021-24785-3},
author = {Clement, Cristina C. and López Cara, Luisa Carlota},
}