@misc{10481/70355,
year = {2021},
url = {http://hdl.handle.net/10481/70355},
abstract = {(1) Background: The replacement of diets high in saturated fat (SAFA) with monounsaturated fatty acids (MUFA) is associated with better cardiovascular function and is related to the
modulation of the activity of the local renin–angiotensin system (RAS) and the collagenase activity of
dipeptidyl peptidase IV (DPP-IV). The objective of the work was to verify the capacity of different
types of dietary fat on the regulatory activities of RAS and DPP-IV. (2) Methods: Male Wistar rats
were fed for 24 weeks with three different diets: the standard diet (S), the standard diet supplemented
with virgin olive oil (20%) (VOO), or with butter (20%) plus cholesterol (0.1%) (Bch). The proteolytic
activities were determined by fluorometric methods in the soluble (sol) and membrane-bound (mb)
fractions of the left ventricle and atrium, aorta, and plasma samples. (3) Results: With the VOO
diet, angiotensinase values were significantly lower than with the Bch diet in the aorta (GluAP and
ArgAP (mb)), ventricle (ArgAP (mb)) and atrium (CysAP (sol)). Significant decreases in DPP-IV (mb)
activity occurred with the Bch diet in the atrium and aorta. The VOO diet significantly reduced the
activity of the cardiac damage marker LeuAP (mb) in the ventricle and aorta, except for LeuAP (sol)
in the ventricle, which was reduced with the Bch diet. (4) Conclusions: The introduction into the
diet of a source rich in MUFA would have a beneficial cardiovascular effect on RAS homeostasis and
cardiovascular functional stability.},
organization = {ACCIÓN 1 PAIUJA 2019 2020: BIO221.},
publisher = {MDPI},
keywords = {Aminopeptidase activity},
keywords = {Angiotensinases},
keywords = {Dipeptidyl peptidase IV},
keywords = {High-fat diet},
keywords = {Virgin olive oil},
title = {High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats},
doi = {10.3390/biomedicines9091149},
author = {Segarra, Ana Belén and Ramírez Sánchez, Manuel and Prieto Gómez, Isabel and Domínguez Vías, German},
}