@misc{10481/70202,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/70202},
abstract = {Tocilizumab (TCZ) has been administered in SARS-CoV-2 pneumonia but the factors
associated with mortality before and after treatment remain unclear. Cox regression
models were used to estimate the predictors of time to death in a cohort of hospitalized
patients with COVID-19 receiving TCZ. In addition, the mean differences between
discharged and deceased patients in laboratory parameters measured before and 3, 6
and 9 days after TCZ administration were estimated with weighted generalized
estimation equations. The variables associated with time to death were
immunosuppression (Hazard Ratio-HR 3.15; 95% confidence interval-CI 1.17,
8.51), diabetes mellitus (HR 2.63; 95% CI 1.23–5.64), age (HR 1.05; 95% CI
1.02–1.09), days since diagnosis until TCZ administration (HR 1.05, 95% CI
1.00–1.09), and platelets (HR 0.27; 95% CI: 0.11, 0.69). In the post-TCZ analysis
and compared to discharged patients, deceased patients had more lactate
dehydrogenase (p   0.013), troponin I (p   0.013), C-reactive protein (p   0.013),
neutrophils (p   0.024), and fewer platelets (p   0.013) and lymphocytes (p   0.013) as
well as a lower average PaO2/FiO2 ratio. In conclusion, in COVID-19 diagnosed
patients receiving TCZ, early treatment decreased the risk of death, while age,
some comorbidities and baseline lower platelet counts increased that risk. After
TCZ administration, lower platelet levels were again associated with mortality,
together with other laboratory parameters.},
publisher = {Frontiers Research Foundation},
keywords = {COVID-19},
keywords = {Immunosupression},
keywords = {Tocilizumab},
keywords = {Mortality},
keywords = {Risk factor},
keywords = {Platelet},
title = {Tocilizumab in COVID-19: Factors Associated With Mortality Before and After Treatment},
doi = {10.3389/fphar.2021.620187},
author = {Sarabia de Ardanaz, Luis and Andreu Ubero, José María and Navidad Fuentes, Miriam and Ferrer González, Miguel Ángel and Ruiz del Valle, Víctor and Salcedo Bellido, Inmaculada and Barrios Rodríguez, Rocío and Cáliz Cáliz, Antonio Rafael and Requena Méndez, María del Pilar},
}